Polyethylene Glycol Loxenatide Pharmacokinetics Study in Subjects With Normal and Insufficiency Renal Function

Inclusion Criteria: 1. Age 31-65 (both inclusive) years old, male or female; 2. Weight: Male ≥50kg, female ≥45kg, 18≤BMI≤28; 3. The Cockcroft-Gault (CG) formula to estimate creatinine clearance (CLCr), K / DOQI definition of chronic kidney disease (CKD) 2 patients: 60≤CLcr≤89 ml / min; chronic kidney disease (CKD) 3 patients: 30≤CLcr≤59 ml / min for renal insufficiency,Cockcroft-Gault (CG) formula to estimate creatinine clearance (CLCr) ≥90ml / min for normal subjects. 4. In the 48 hours before the start of the test to the end of the trial period, agreed to get rid of tobacco, alcohol, caffeine, fruit juice subject; 5. Understand the study procedures and methods, voluntarily participate in this experiment, and writing and signed informed consent. Exclusion Criteria: 1. Known or suspected of GLP-1 class of drug allergy or allergy; 2. Before screening,received GLP-1 receptor agonists, GLP-1 analogs, DPP-IV inhibitors or any other similar structure of the drug treatment; 3. In addition to the induced renal dysfunction disease itself, suffering from any other organ of acute illness and those with any influence of drugs in vivo study of chronic diseases; 4. within 6 months prior to screening,having any surgery, including the impact of gastric emptying of gastrointestinal surgery; 5. Screened within the previous three months to participate in blood donation and blood donation ≥400mL, or who participate in blood donation or blood transfusion within one month; 6. Within 3 months before screening participated in any drug or medical device trials are (including placebo); 7. Drinking, smoking addiction, drug abuse and drug abusers; 8. In addition to judging laboratory abnormalities diagnosis of renal dysfunction caused by disease, there are other clinically significant laboratory abnormalities (Note: Patients with moderate to severe anemia (Hb \<60g / L), severe hypertension ( SBP\> 160mmHg and / or diastolic blood pressure\> 100mmHg) patients, heart rate\> 100bmp, ECG QTc\> 450ms were required to exclude; 9. ALT\> 1.5 times the upper limit of normal and / or aspartate transaminase\> 1.5 times the upper limit of normal and / or total bilirubin\> 1.5 times the upper limit of normal; 10. Fasting triglycerides\> 5.64mmol / L (500mg / dl); 11. Beyond the normal range of serum amylase, and the clinical significance is determined by the investigator; 12. Pancreatitis, pancreatic cancer a history; 13. Blood thyroid stimulating hormone (TSH) beyond the normal range and clinically significant judgment by the investigator; 14. The pregnancy test was positive women of childbearing age, or pregnant women, breastfeeding women, and within six months there have been unwilling or unable to take family planning and effective contraception during the trial of male / female volunteers; 15. The hepatitis B surface antigen, hepatitis C antibody, HIV antibody, syphilis antibody test positive; 16. Researchers believe any situation that might lead to any subject can not be completed or to the subject of this study bring significant risk.