AngioDefender Versus Brachial Artery Ultrasound Imaging

Inclusion Criteria: * ECOG 0-2 Exclusion Criteria: 1. Body mass index (BMI) \>50 kg/m2 2. Mid-upper arm circumference of arm selected for FMD testing \<17 cm or \>40 cm 3. Sinus arrhythmia (RR intervals vary by \>50%), atrial fibrillation, atrial flutter, multifocal atrial tachycardia, frequent (\>1 per 10-sec strip) premature atrial or ventricular contractions (isolated, non-isolated, or alternating), documented by 12-lead ECG with rhythm strip at the time of subject screening. 4. Clinical signs and/or symptoms of active viral or bacterial infections 5. Resting tremor or inability to remain still for the duration of AD and BAUI testing 6. Systolic blood pressure (SBP) at rest of \>170 mmHg or diastolic blood pressure (DBP) at rest of ≥110 mmHg. 7. Previous intolerable adverse reaction(s) to vascular testing using an upper extremity occlusive pneumatic cuff