Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions

Meir Medical Center30 enrolled

Overview

There is a pressing need to find effective strategies for the prevention of contrast induced nephropathy in patients with advanced renal dysfunction. The current study was designed to assess the efficacy of a new protocol for preventing contrast induced nephropathy in patients with advanced renal dysfunction undergoing coronary interventions

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Kidney Disease, Chronic Ischemic Heart Disease

Interventions

Percutaneous coronary interventionPROCEDURE

Patients planned for coronary angiography or percutaneous coronary intervention will be managed using a protocol that allows us to use minimal volumes of contrast dye

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients with estimated glomerular filtration rate\<45ml/min undergoing coronary angiography due to one of the following indications in accordance with the 2014 guidelines: 1. Elective coronary angiography due to symptoms suggestive for angina with a positive non-invasive ischemia assessment of ≥10% of left ventricle. 2. Non ST-elevation acute coronary syndrome with a GRACE score\>110 Exclusion Criteria: * Patients on dialysis or those planned for dialysis in the next 3 months. * Patients with ST-elevation myocardial infarction * No symptoms or signs of heart failure * Treatment with IV diuretics during the 48 hours prior to enrolment * Patients with acute renal failure (Creatinine raise of at least 0.3mg/dl from )baseline * Patients post coronary artery bypass surgery

Locations (1)

Meir Medical Center

Kfar Saba, Israel, Israel

Outcomes

Primary Outcomes

Changes in glomerular filtration rate following coronary angiography or intervention

Significant changes are defined as a reduction ≥25% in glomerular filtration rate

Time frame: 24 and 48 hours post procedure

Data from ClinicalTrials.gov

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