Xenon Against Postoperative Oxygen Impairment

Beijing Anzhen Hospital160 enrolled

Overview

Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no suppression on the cardiovascular system. Furthermore, our earlier trial has already clarified that static inflation with 50% Xenon during cardiopulmonary bypass could attenuate ALI for Standford A acute aortic dissection. However the protection effect was restricted for the limited time. Aimed to enhance the protection effect of Xenon, we designed this randomized trial that anesthesia with 50% xenon one hour before and after CPB and pulmonary static Inflation with 50%,75% and 100% Xenon during CPB respectively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

160

Conditions

Acute Lung Injury

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria Consultant's clinical diagnosis of Stanford type A AAD using local pathways of diagnosis, which may include clinical history, chest radiography (X-rays), transthoracic ultrasound, and contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) Patients aged 18 to 65 years Eligible for AAD surgery Exclusion Criteria Have coronary heart disease, heart failure, severe cardiac tamponade, unstable hemodynamics, severe nervous system abnormalities, clinically apparent malperfusion\[9\] including lower limb, cerebral, coronary and renal malperfusion, and visceral ischemia, sever hepatic and renal abnormalities Have undergone any of the cardiac and thoracic surgeries Are unlikely to be able to perform the required clinical assessment tasks Have significant cognitive impairment or language issues Are unable to provide consent with regard to their participation in the study Prescribed with non-steroidal anti-inflammatory drugs or corticosteroids before or after admission

Outcomes

Primary Outcomes

oxygenation index

Time frame: perioperative period

Secondary Outcomes

alterations in cytokine and ROS in the perioperative period

Time frame: perioperative period

extubation time

Time frame: perioperative period

complications of vital organs

Time frame: perioperative period

Xenon Against Postoperative Oxygen Impairment

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts