The purpose of this study is to compare the preventive effect of electroacupuncture and sham acupuncture on acute chemotherapy-induced nausea and vomiting and then investigate its potential mechanism by using functional Magnetic Resonance Imaging (fMRI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
160
The needles used were Huatuo brand (Suzhou, China) sterile disposable stainless steel filiform; needles sized 0.25\*25 mm. After disinfection, needles were inserted 0.5 to 0.8 inches into the skin and were manipulated manually to obtain Deqi. An electric stimulator (Huatuo SDZ-V, Suzhou, China) was connected to the needles and delivered a constant-current, 0.2-ms, density-wave, stimulus of 2 to 10-Hz frequency, level of intensity was as much as tolerable, but not painful to the subjects. The needles were left for 30 minutes and then removed.
Xijing Hospital
Xi'an, Shaanxi, China
RECRUITINGThe scores of Rhodes Index of Nausea, Vomiting and Retching.
Time frame: 24 hours
Content of 5-hiaa in urine
Time frame: 12 hours
Heart Rate Variability
Time frame: 1 hour
Tachygastria percentage
Time frame: 1 hour
Dosage of antiemetic drugs
Time frame: 24 hours
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