Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy

Assiut University40 enrolled

Overview

The investigators aim to investigate the differences between deep continuous muscle relaxation and moderate blockade during low-pressure (8 mmHg) laparoscopic cholecystectomy in respect to metabolic changes and respiratory mechanics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Laparoscopic Cholecystectomy

Interventions

RocuroniumDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * more than 18 years * undergoing elective laparoscopic cholecystectomy Exclusion Criteria: * previous surgeries, * a history of venous or arterial diseases, * BMI (≥30 kg/m2), * Allergy to rocuronium. * Significant liver dysfunction. * Significant renal dysfunction (S-creatinine \> 200 umol/l). * Neuromuscular disease that might impair neuromuscular blockade * Pregnant or breastfeeding. * Indication for rapid sequence induction. * Inability to informed consent

Locations (1)

Al Rajhy liver hospital

Asyut, Asyut Governorate, Egypt

Outcomes

Primary Outcomes

respiratory mechanics (Dynamic compliance)

Dynamic compliance

Time frame: intraoperative

Secondary Outcomes

surgeon satisfaction (scale from 1 to 5)

scale from 1 to 5

Time frame: intraoperative

postoperative pain (VAS score)

VAS score

Time frame: postoperative for 6 hours

postoperative nausea and vomiting

Time frame: postoperative for 6 hours

completion of surgical procedure

yes or no

Time frame: intraoperative

metabolic changes (blood lactate)

blood lactate

Time frame: intraoperative

Data from ClinicalTrials.gov

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