Positron Emission Tomography (PET) During Radio-chemotherapy to Treat Otorhinolaryngological Cancer

Inclusion Criteria: * Age ≥ 18 years and ≤ 75 years * invasive epidermoid carcinoma of head and neck (excluding nasopharyngeal), confirmed by histology * locally advanced disease (non-metastatic stages AJCC III-IV). AJCC = American Joint Committee on Cancer * performance status ECOG ≤ 2. ECOG = Eastern Cooperative Oncology Group * no history of irradiation of the head and neck * start of radiotherapy within 8 weeks after the pretreatment PET Scan * no surgery other than biopsy * pregnancy test: negative for women of childbearing potential * reliable contraception for a childbearing couple, men and woman must have a reliable contraception during treatment * signed informed consent form * patient with national health insurance Exclusion Criteria: * prior radiotherapy or chemotherapy * history of other cancer except: cutaneous non-melanoma tumor and cervix in situ carcinoma * unstable conditions (cardiovascular, renal, pulmonary) or systemic (lupus erythematosus, scleroderma) * pregnant patient or patient with breastfeeding * patient unable to give his consent * patient under administrative supervision * patient who participates to another clinical trial on experimental drug * regular follow-up impossible for various reasons (familial, economical, social, ...) * diabetes * accelerated radiotherapy protocol