This trial is conducted in Europe. The aim of this trial is to compare NNC0123-0000-0338 (insulin-338) in a tablet formulation and insulin glargine in combination with metformin with or without DPP-4 inhibitor in subjects with type 2 diabetes currently treated with oral antidiabetic therapy
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
50
Oral administered once daily in combination with metformin with or without DPP-4 inhibitor
Injected s.c./subcutaneously (under the skin) once daily in combination with metformin with or without DPP-4 inhibitor
Administered once daily
Novo Nordisk Investigational Site
Mainz, Germany
Novo Nordisk Investigational Site
Neuss, Germany
Change in fasting plasma glucose (FPG)
Time frame: Week 0, Week 8
Change from baseline in 10-points plasma glucose profile
Time frame: Week 0, Week 8
Number of treatment emergent hypoglycaemic episodes
Time frame: From start of treatment until Visit 14 (Day 68)
area under the serum insulin concentration-time curve
Time frame: During one dosing interval (0 to 24 hours) at steady state (Day 56)
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