Sodium Alendronate in Non Surgical Periodontal Therapy

Federal University of Minas Gerais32 enrolled

Overview

In the past few years, studies have evaluated the effect of systemic use of sodium alendronate, especially in the treatment of structural bone defects caused by periodontal diseases. This study evaluated the effects of non-surgical periodontal treatment associated with the topical application of 1% sodium alendronate on clinical and topographical parameters. Chronic periodontitis patients were recruited for the present study and were monitored at 3 and 6 months after baseline examinations. A placebo gel was used as control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontitis Bone Resorption

Interventions

Sodium alendronateDRUG

After manual quadrant-wise scaling and root planing, at the final treatment appointment the randomized selected periodontal site (showing pocket depth ≥ 5mm, clinical attachment loss \> 3mm and proximal bone defects) received 1% sodium alendronate gel

PlaceboOTHER

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic periodontitis * two contralateral teeth showing periodontal pocket depth ≥ 5mm, clinical attachment loss \> 3mm, proximal vertical bone defects, no prosthetic device, without caries lesions, proximal dental contact and lack of premature occlusal contact * systemically healthy volunteers Exclusion Criteria: * need for antibiotic or systemic/local antibiotic use in the previous 3 months * periodontal treatment in the previous 6 months * pregnancy or lactation * immunological disorders or imune suppressive treatments * diabetes * smoking * orthodontic appliances or removable prosthesis * osteoporosis * known or suspected allergy to biphosphonates * systemic use of biphosphonates

Locations (1)

Dental clinic of pontifical catholic university

Belo Horizonte, Minas Gerais, Brazil

Outcomes

Primary Outcomes

Changes in pocket depth

Reductions in pocket depth overtime

Time frame: baseline and 3- and to 6-month evaluations

Changes in clinical attachment level

Gain in clinical attachment level overtime

Time frame: baseline and 3- and to 6-month evaluations

Secondary Outcomes

Changes in bone defects

Reduction in bone defects by bone filling

Time frame: Baseline and 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.