Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)

INCLUSION CRITERIA: * Provide informed consent * Age ≥ 18 years and of either sex * Willing to comply with protocol instructions, including allowing all study assessments * Have a Venous Leg Ulcer (VLU) between the knee and ankle (at or above the malleolus), with a surface area ≥ 2.0 cm2 and ≤ 36.0 cm2 * Target ulcer duration ≥ 4 weeks but ≤ 104 weeks (24 months) * Have a Diabetic Foot Ulcer (DFU) present on any part of the plantar or dorsum surface of the foot, with a surface area ≥ 0.5 cm2 and ≤ 10.0 cm2 * Target ulcer involves a full thickness skin loss, but WITHOUT exposure of tendon, muscle, or bone * Target ulcer duration ≥ 4 weeks but ≤ 52 weeks (12 months) * Acceptable state of health and nutrition EXCLUSION CRITERIA * Therapy with another investigational agent within thirty (30) days of Screening, or during the study Ulcers which are deemed as highly exuding, per the Investigator's discretion. * Current diagnosis of osteomyelitis at the target wound location that is not currently receiving treatment \[Documented history of resolved osteomyelitis is allowed\]. * Subjects with a VLU: Refusal of or inability to tolerate compression therapy. * Clinical evidence of target ulcer infection * Current systemic therapy with cytotoxic drugs. * Current therapy with chronic (\> 10 days) oral corticosteroids. * Previous treatment with NPWT device or hyperbaric oxygen within 7 days of screening. * Malignancy in the target ulcer, or history of cancer in the preceding 5 years (other than carcinoma in situ of the cervix or adequately treated non-melanoma skin cancers)