To evaluate the effect of mild, moderate, or severe hepatic impairment on the pharmacokinetics (PK) of a single dose of 400 mg sotagliflozin (2 x 200-mg tablets) compared with healthy, demographically-matched subjects.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
32
single 400 mg dose
Lexicon Investigational Site
Lakewood, Colorado, United States
Lexicon Investigational Site
Miami, Florida, United States
Lexicon Investigational Site
Orlando, Florida, United States
Lexicon Investigational Site
Minneapolis, Minnesota, United States
Plasma concentration of sotaglifozin to evaluate protocol specified PK parameters
Time frame: Day 1 to Day 5
Number of treatment emergent adverse events
Time frame: Day 1 to Day 8
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