The aim of this study is to determine the effects of a low Fermentescible Oligosaccharides Disaccharides Monosaccharides and Polyols (FODMAP) diet in patients with documented refractory GERD on proton pump inhibitor (PPI) therapy.
Colonic fermentation has been shown to influence oeso-gastric motility : increased gastric relaxation, increased rate of lower esophageal sphincter relaxation. Experimental increased colonic fermentation (FOS in diet) increase the occurrence of reflux events in patients with GERD. The aim of this study is to compare the low-FODMAP diet and classical GERD dietary recommendations (avoid fatty meals, head of bed elevation etc..) in patients with refractory GERD symptoms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
31
Hépato-Gastroentérologie et oncologie digestive,
Bordeaux, France
Gastroentérologie
Colombes, France
Explorations fonctionnelles
Lyon, France
Gastroentérologie
Nantes, France
Percentage of patients with clinical remission as defined by a RDQ score ≤ 3
Time frame: at Week 4 of diet
Between-group comparison of efficacy
This measure is a composite with : * Reflux Disease Questionnaire (RDQ) scores * Francis Irritable Bowel Syndrome (IBS) score * Quality of life (GIQLI) score * and reflux parameter on pH-impedance monitoring
Time frame: at Week 4 of diet
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Explorations fonctionnelles Digestives
Rennes, France
Gastroentérologie
Rouen, France