To determine if 6 months of legume-based complementary foods is effective in reducing or reversing EED and linear growth faltering in a cohort of Malawian children, aged 6-11 months to see if these improvements are correlated with specific changes in the enteric microbiome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
355
A legume-based complementary food made from cowpeas will be given for 6 months, 200 kcal/day for children 6-9 months old and 300 kcal/day for children 9-11 months old.
Corn flour with 10% soy will be given for 6 months, 200 kcal/day for children 6-9 months old and 300 kcal/day for children 9-11 months old.
A legume-based complementary food made from common beans will be given for 6 months,200 kcal/day for children 6-9 months old and 300 kcal/day for children 9-11 months old.
University of Malawi
Blantyre, Malawi
Change in Length-for-age z Score Over 6 Months From Enrollment to End of Study.
Change in length-for-age z score from enrollment to end of study 6 months
Time frame: 6 months
% Lactulose From Dual Sugar Absorption Test at 9 and 12 Months of Age
percent of lactulose found in urine during the dual sugar absorption test
Time frame: 6 month
16S Configuration of Fecal Microbiota at 6.5, 7.5, 9, 10.5 and 12 Months of Age Comparing Supplementary Food Groups
Time frame: 6 months
Mid-upper Arm Circumference at 9 and 12 Months of Age
Mid-upper arm circumference in cm
Time frame: 6 months
Weight-for-height z Score at 9 and 12 Months of Age
weight for height z-score at 9 and 12 months of age
Time frame: 6 months
Association of 16S Configuration of Fecal Microbiome With Demographic, Anthropometric, Intestinal Permeability, Sanitation and Antibiotic Exposure Characteristics of the Study Population
Time frame: 6 months
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