A Study Evaluating the Effect of Esomeprazole on SYN-004 Degradation of Ceftriaxone In Adults With an Ileostomy

Inclusion Criteria: * The subject has a functioning ileostomy that has been in place for ≥ 3 months. * The subject is male or female between the ages of 18 and 80 years, inclusive. * Other than a functioning ileostomy, the subject is free from clinically significant illnesses or disease. Exclusion Criteria: * Subjects who have active hepatic, small intestine, or biliary tract disease. * Subjects who have active ulcerative colitis, Crohn's disease, other inflammatory bowel disease. * Subjects with known malignancy requiring treatment \< 6 months prior to study screening. * Subjects who have, in the opinion of the investigator, significant concurrent medical illness. * Subjects who are currently taking concomitant medications which may interfere with study evaluation. * Subjects who have received an investigational drug within 30 days or within a time period consistent with a washout period of 5 half-lives, whichever is longer, of the first dose of ceftriaxone. * Subjects with a known history of allergy to any cephalosporin, penicillin or any β-lactam antibiotic. * Subjects who have known active malabsorption syndromes(s) that, in the judgment of the investigator, could compromise the objectives of the study. * Subjects who have used any oral, intramuscular, or IV anti-microbial medication during the last 3 week