Study of Topical Ocular PAN-90806 in PDR

Inclusion Criteria: * Aged 18 years or older with type 1 or type 2 diabetes * Proliferative diabetic retinopathy (PDR) in study eye retina with or without diabetic macular edema (DME) involving the center of the macula * Demonstrate the ability, or have a family member who is willing and able, to instill topical ocular drops in the study eye Exclusion Criteria: * Current or recent use (within the last 3 months) of anti-vascular endothelial growth factors (anti-VEGF) in either eye; * Uncontrolled hypertension despite use of antihypertensive medications * Unwillingness to refrain from wearing contact lenses for the duration of the study. * Participation in any investigational drug or device study, systemic or ocular, within past 3 months * Women who are pregnant or nursing * Known serious allergies or hypersensitivity to the fluorescein dye used in angiography or to the components of the PAN-90806 formulation