A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers

Inclusion Criteria: * Participant willing and able to give informed consent * Male or Female, aged 18-65 years at Visit 1 * Forced expiratory volume at one second (FEV1) \>80% predicted * FEV1/forced vital capacity (FVC) ratio ≥70% * Non-smoker for \>1 year with \<10 py smoking history * Female participants of child bearing potential must ensure use of effective contraception during the study * Participants has clinically acceptable laboratory and ECG at screening * A chest x-ray confirming the absence of significant lung disease * A negative result to skin prick testing with common aeroallergens, or, if a skin prick test to a common aeroallergen is positive, a negative response to challenge with methacholine (defined as a provocative concentration causing a 20% fall in FEV1 \[PC20 methacholine\] \>16 mg/ml) * Able (in the Investigators opinion) and willing to comply with all study requirements Exclusion Criteria: * Failure to meet the inclusion criteria * Female participants who are pregnant, lactating or planning pregnancy during the course of the study * History of a severe allergic reaction or anaphylaxis to corticosteroids * Systemic treatment with corticosteroids within last 6 months * Any infection that resulted in hospital admission for ≥ 24 hours within 4 weeks prior to Visit 1 or during screening * Any infection that required treatment with IV or intramuscular (IM) antibiotics within 4 weeks prior to Visit 1 or during screening * Any active infection that required treatment with oral antibiotics within 2 weeks prior to Visit 1 or during screening * Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening * Active tuberculosis requiring treatment within 12 months prior to Visit 1 * Known immunodeficiency including but not limited to HIV infection * Evidence of acute or chronic hepatitis or known liver cirrhosis * Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or total bilirubin elevation ≥2.0 × the upper limit of normal (ULN) during screening * Clinically significant abnormality on screening ECG or laboratory tests (haematology, serum chemistry, and urinalysis) that, in the opinion of the investigator, may pose an additional risk in administering study drug to the patient or performing bronchoscopy * Known current malignancy or current evaluation for a potential malignancy * Unable to safely undergo elective flexible fiberoptic bronchoscopy because of any one of the following: * History of allergic reaction to local anesthetics to be used during the bronchoscopy * Presence of clinically significant abnormality on Screening Coagulation Panel * Presence of clinically significant medical comorbidities that, in the opinion of the investigator, may make the patient unsuitable for elective bronchoscopy or would impact on study efficacy assessments * A history of atopic disease (allergic rhinitis \[perennial or seasonal\], atopic dermatitis, food allergy) * History of alcohol or drug abuse that would impair or risk the patient's full participation in the study, in the opinion of the investigator * Current smoker, former smoker with smoking history of \>10 pack-years. * Treatment with anticoagulant medications including but not limited to aspirin,warfarin or antiplatelet medication * Use of a licensed or investigational monoclonal antibody within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) * Use of a systemic immunomodulatory or immunosuppressive therapy within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer). * Use of other investigational therapy not described above within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) * Receipt of a live attenuated vaccine within 4 weeks prior to Visit 1 * Use of complementary, alternative, or homeopathic medicines including, but not limited to traditional or non-traditional herbal medications within 3 months * Scheduled elective surgery or other procedures requiring general anaesthesia during the study * Donation of blood during the study or within the past 12 weeks * BMI \>38 kg/m2 * Body weight \<40 kg