Comparison of the Pharmacokinetic Properties of Two Tablet Formulations of Macitentan in Healthy Adults

Inclusion Criteria: * Signed informed consent * Healthy on the basis of the physical examination, vital signs (systolic and diastolic blood pressure, heart rate), 12-lead ECG, and laboratory tests performed at screening Exclusion Criteria: * History or clinical evidence of any disease and/or condition, which might interfere with the absorption, distribution, metabolism or excretion of the study drug * Previous history of fainting, collapse, syncope, orthostatic hypotension, or vasovagal reactions * History or clinical evidence of alcoholism or drug abuse within the 3 -year period prior to screening * Excessive caffeine consumption * Smoking within 3 months prior to screening and inability to refrain from smoking during the course of the study * Previous treatment with any prescribed medications (including vaccines) or over-the counter medications within 2 weeks prior to first study drug administration * Loss of 250 mL or more of blood within 3 months prior to screening * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol