A Prospective, Multi-Center, Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter in Facilitating Crossing Chronic Total Occlusion (CTO) Coronary Lesions

Inclusion Criteria: * Adult aged 25-80 * Patient understands and has signed the study informed consent form. * Patient has an angiographic documented Chronic Total Occlusion (i.e. \>3 months occlusion duration) showing distal TIMI flow 0. * Suitable candidate for non-emergent, coronary angioplasty * Documented coronary angiography preceding the PCI reveals at least one CTO lesion situated in a non-infarct related coronary artery or its side branches * Body Mass Index (BMI) \< 40 * Left ventricle ejection fraction \> 25% Exclusion Criteria: * Patient unable to give informed consent. * Current participation in another study with any investigational drug or device. * Patient is known or suspected not to tolerate the contrast agent. * Aorta-ostial CTO location (Ostial bifurcation origins may be considered), SVG CTO, in-stent CTO. * Intolerance to Aspirin and/or inability to tolerate a second antiplatelet agent (Clopidogrel and Prasugrel and Ticagrelor). * Appearance of a fresh thrombus or intraluminal filling defects. * Recent major cerebrovascular event (history of stroke or TIA within 1 month) * Cardiac intervention within 4 weeks of the procedure * Renal insufficiency (serum creatinine of \> 2.3mg/dl or 203μmol/L) * Active gastrointestinal bleeding * Active infection or fever that may be due to infection * Life expectancy \< 2 years due to other illnesses * Significant anemia (hemoglobin \< 8.0 mg / dl) * Severe uncontrolled systemic hypertension (\> 240 mmHg within 1 month of procedure) * Severe electrolyte imbalance * Congestive heart failure \[New York Heart Association (NYHA) Class III\\IV\] CSA Class IV. * Unstable angina requiring emergent percutaneous trans-luminal coronary angioplasty (PTCA) or coronary artery bypass graft (CABG) * Recent myocardial infarction (MI) (within the past two weeks) * Uncontrolled diabetes \>2 serum glucose concentrations of \>350 mg/dl within 7 days. * Unwillingness or inability to comply with any protocol requirements * Pregnant or nursing * Extensive prior dissection from a coronary guidewire use * Drug abuse or alcoholism. * Patients under custodial care. * Bleeding diathesis or coagulation disorder; * Kawasaki's disease or other vasculitis