Study of Adsorption Tetanus-diphtheria-acellular Pertussis (DTaP) Vaccine in Healthy 3 to 5 Months Infants

Inclusion criteria: * Healthy infants aged 3-5months old as established by medical history and clinical examination * The subjects' guardians are able to understand and sign the informed consent * Subjects who can and will comply with the requirements of the protocol * Subjects with temperature ≤37.0°C on axillary setting Exclusion criteria: * Subjects who was premature birth * Subjects who has a medical history of diphtheria, pertussis or tetanus. * Had been vaccined for DTwP or DTaP * Subject that has a medical history of any of the following: allergic history, or allergic to any ingredient of vaccine * Severe malnutrition or dysgenopathy * Family history of seizures or progressive neurological disease * Family history of congenital or hereditary immunodeficiency * Thyroid disease * Coagulation disorder diagnosed by a doctor(such as the lack of clotting factors, clotting hemorrhagic disease, platelet abnormalities) or significant bruising * No spleen, functional asplenia, and any situation caused by no spleen or splenectomy * Any acute infections in last 7 days * Any prior administration of immunodepressant or corticosteroids * Any prior administration of blood products in last 3 month * Any prior administration of other research medicines in last 1 month * Any prior administration of attenuated live vaccine in last 15 days * Any prior administration of subunit or inactivated vaccines in last 7 days * Had fever before vaccination, Subjects with temperature \>37.0°C on axillary setting * Any condition that in the opinion of the investigator, may interfere with the evaluation of study objectives Exclusion criteria for the second and third dose: If subjects who have one condition of 1 to 4 as followed, prohibiting to continue the vaccination, and they will be continue observed in the opinion of the investigator. If Subjects who had one condition of 5 to 6 as followed, must be determined whether to continue by the investigator. If Subjects who had one condition of 7 to 8 as followed, they can had a delayed vaccination during time frame of the program. All participants with adverse events as followed, must be settled in follow-up to the end of events. * Any serious adverse events caused by vaccination. * Hypersensitivity after vaccination. * Anaphylaxis after vaccination * Any confirmed or suspected autoimmune diseases or immune deficiency disorders, including human immunodeficiency virus (HIV) infection * Have acute or new chronic disease during vaccination * Other reactions that in the opinion of the investigator ( include: severely serious symptom of pain, swelling, Limitation of motion, continuous high fever, headache and other Systemic or local reactions ) * Have acute disease during vaccination (Acute disease refers to with or without fever of moderate or severe disease) * Subjects with temperature \>37.0°C on axillary settin.