Pilot Study of Mobilization and Treatment of Disseminated Tumor Cells in Men With Metastatic Prostate Cancer

Inclusion Criteria: 1. Have signed an informed consent document indicating that the subject understands the purpose of and procedures required for the study and are willing to participate in the study 2. Be willing/able to adhere to the prohibitions and restrictions specified in this protocol 3. Male aged 18 years and above 4. Eastern cooperative group (ECOG) performance status ≤2 5. Documented histologically confirmed adenocarcinoma of the prostate 6. Metastatic prostate cancer to the bone as documented by positive bone scan imaging 7. Patient must be eligible for chemotherapy with docetaxel 8. Patient must have evidence of castrate resistant prostate cancer as evidenced by a confirmed rising PSA (per Prostate Cancer Working Group 2 \[PCWG2\] criteria) and a castrate serum testosterone level (i.e. ≤ 50 mg/dL). Exclusion Criteria: 1. Have known allergies, hypersensitivity, or intolerance to docetaxel or dexamethasone or their excipients 2. Prior pelvic radiation (e.g. external beam, brachytherapy, etc) that, in the opinion of the investigator, may lead to decreased bone marrow cellularity in a marrow sample obtained from a pelvic bone marrow biopsy 3. Ongoing systemic therapy (other than a GnRH agonist/antagonist) for prostate cancer including, but not limited to: 1. CYP-17 inhibitors (e.g. ketoconazole, abiraterone) 2. Antiandrogens (e.g. bicalutamide, nilutamide) 3. Second generation antiandrogens (e.g. enzalutamide) 4. Immunotherapy (e.g. sipuleucel-T, ipilimumab) 5. Chemotherapy (e.g. docetaxel, cabazitaxel) 4. Prior radiopharmaceutical therapy (e.g. radium-223, strontium-89, samarium-153, etc) within the past year 5. Have any condition that, in the opinion of the investigator, would compromise the well-being of the subject or the study or prevent the subject from meeting or performing study requirements 6. Active infection or other medical condition that would make corticosteroids (i.e. dexamethasone) use contraindicated 7. Uncontrolled hypertension (systolic BP ≥ 160 mmHg or diastolic BP ≥ 95 mmHg) Patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment 8. Severe hepatic impairment (Child-Pugh Class C) 9. History of pituitary or adrenal dysfunction (note: the use of daily steroids does not exclude someone from participating in this study) 10. Have poorly controlled diabetes (HgB A1C ≥ 8%) 11. Any psychological, familial, sociological, or geographical condition that could potentially interfere with compliance with the study protocol and follow-up schedule.