This study will evaluate, if an intensive individually adaptated training program via online supervision during neoadjuvant therapy will improve lung function and reduce pulmonary complications following esophagectomy for Barrett's cancer.
Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonal complications. This may be partly due to one-lung ventilation during the thoracic part of the operation. This often encounters for prolonged periods of reconvalescence and reduced quality of life, apart from socioeconomic disadvantages. Physical preconditioning has become a crucial leverage to optimize fitness and lung function in patients scheduled for esophagectomy, in particular during the interval of neoadjuvant therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Patients undergo internet-based perioperative exercise program (iPEP), including daily endurance, resistance and ventilation training
Department of Visceral, Transplantation, Vascular and Thoracic Surgery
Leipzig, Germany
RECRUITINGpeak oxygen uptake (VO2peak)
First measurement three months prior to surgery (baseline), Second measurement immediately before surgery, third measurement three months after esophagectomy
Time frame: 6 months
Gastric conduit failure after esophagectomy
(type classification according to Veeramootoo et al. (2009)) Evaluation of postoperative in-hospital stay
Time frame: intraoperative
pneumonia
Evaluation of postoperative in-hospital stay
Time frame: intraoperative
duration of mechanical ventilation
Evaluation of postoperative in-hospital stay
Time frame: intraoperative
re-intubation rate
Evaluation of postoperative in-hospital stay
Time frame: intraoperative
Duration of intensive care unit stay
Evaluation of postoperative in-hospital stay
Time frame: intraoperative
quality of life
Quality of life questionnaire (QoLQ-C30) with the esophagus-specific module OES-18. First measurement three months prior to surgery (baseline), immediately before surgery, three months after esophagectomy
Time frame: 6 months
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