This research is being done to see if resistance exercise (RE) is safe and has a positive effect on children and young adults with juvenile idiopathic arthritis (JIA). JIA is an inflammatory autoimmune disease that can cause severe impairment and disability. JIA can cause bone loss and decreased muscle strength. The medications used to treat JIA can also have negative effects on growth and development, strength, and ability to function. RE is performing movements in a slow and controlled fashion (i.e., no speeding up or using force in the lifting and lowering of the weight) to lessen force on the joints and tissues. This study will be using Ren-Ex exercise equipment to perform RE. Currently the American College of Rheumatology recommends exercise for patients with arthritis. This exercise includes range of motion exercise to protect joint mobility as well as low resistance and aerobic exercise (AE) to protect muscle mass, bone health, and fitness. However, a recent study showed no major differences in functionality or quality of life between patients who performed AE and those who did not perform AE. There is a need for more data on the impact of RE on children with JIA. Children and young adults aged 10 to 21 with juvenile idiopathic arthritis may join.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Enrollment
33
The exercise is performed once per week with individualized instruction using moderate resistance on Ren-Ex Machines, ultra-low-friction equipment to minimize force on joints.
To study body composition
To study muscle strength
To study lung capacity, a sub-maximal (limited exercise) test on a stationary bicycle is performed.
Johns Hopkins University
Baltimore, Maryland, United States
Change in Total Body Dual-Emission X-ray Absorptiometry (DEXA) Scan
Total and lean body mass and fat mass will be determined
Time frame: Baseline and 12 weeks
Change in BMI
Time frame: Baseline and 12 weeks
Change in Lower and upper extremity strength testing
Isokinetic strength testing with a Biodex dynamometer to measure peak torque
Time frame: Baseline and 12 weeks
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Time frame: Baseline and 12 weeks
Change in Erythrocyte sedimentation rate (ESR)
Time frame: Baseline and 12 weeks
Change in Quality of Life
Questionnaire administration
Time frame: Baseline and 12 weeks
Change in C-reactive protein (CRP)
Time frame: Baseline and 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.