After cardiac surgery, vasoplegic syndrome is a hemodynamic state characterized by profound hypotension associated with a decrease in systemic vascular resistance. The care of this disease is based on the intravenous administration of a vasopressor, usually norepinephrine. During the recovery phase, weaning of norepinephrine, is an important step in which any lack of preload (blood volume) initial or secondary can be, and increase tissue malperfusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
130
Administration and weaning of norepinephrine is based on dynamic arterial elastance
The usual procedure of withdrawal norepinephrine is based on hemodynamic parameters (blood pressure, cardiac output), clinical (cutaneous perfusion, mottling, hourly diuresis) and biological (SVO2, arterial lactate).
CHU Amiens-Picardie
Amiens, Picardie, France
The duration of treatment with norepinephrine.
Mean duration time of norepinephrine administration calculated in hours
Time frame: Day 28
The total dose of norepinephrine infused during the study period
Time frame: Day 28
ICU duration of stay in day
Time frame: Day 28
Total urine output in ml during the study period
Time frame: Day 28
Total of crystalloid an colloid infused during the study period (ml)
Time frame: Day 28
the rate of arterial lactate at the end of norepinephrine administration
Time frame: Day 28
Incidence of postoperative atrial arrhythmias (Ac/Fa, Ventricular tachycardia, Ventricular flutter, Ventricular fibrillation) during the study period
Time frame: Day 28
SOFA score
SOFA score measured at the end of norepinephrine administration
Time frame: Day 28
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