Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity. Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood. Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.
Study Type
OBSERVATIONAL
Enrollment
106
compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects
Time frame: pre operative
follow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures
Time frame: pre operative, 3-, 6-, 9- and 12 months post operative
compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects
Time frame: 12 months post operative
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