A randomized clinical trial to assess the effectiveness of same-day cervical preparation with oral, buccal or vaginal Misoprostol, given 2-4 hours prior first trimester curettage.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
120
Edith Wolfson Medical Center
Holon, Israel
RECRUITINGPreoperative cervical width in centimeters
• Initial cervical dilatation assessed by performing cervical dilatation , beginning with a number 10 Hegar dilator and subsequently inserting smaller Hegar dilators until the dilator can pass through the internal os without resistance. The largest one to pass will consist the initial cervical width.
Time frame: intraoperative
Time required to achieve cervical dilatation
The time in minutes required for dilatation up to a number 10 Hegar
Time frame: intraoperative
Ease of cervical dilatation
The subjective ease of cervical dilatation recorded by the surgeon on a 5-point Likert scale (1-very difficult, 5- very easy
Time frame: intraoperative
Patient preference
Patient acceptability of the administration of medication on a 5-point Likert scale (1-very uncomfortable, 5-very comfortable)
Time frame: baseline
Adverse effects of medication
Self reported misoprostol-associated adverse effects before the procedure (such as nausea, vomiting)
Time frame: baseline
Surgical complications
Complications arising during surgery (perforation, cervical laceration, excess bleeding)
Time frame: intraoperative
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