Silent Breast Cancer A Study of the Disease Prevalence Held by Imaging Guided Biopsies in Autopsy Specimens

Centro Hospitalar Lisboa Ocidental768 enrolled

Overview

The aim of this study is to define silent breast cancer prevalence in both sexes and will be held by biopsies performed in imaging suspicious areas of the breast (ecography and mammography) in cadavers without known breast cancer.

Cadavers of both sexes are going to be submitted to bilateral mastectomy. The specimens are going to be examined by palpation, ecography and mammography and all areas with (Breast Imaging Reporting and Data System) BI-RADS classification \>= 3 are going to be biopsied. Biopsy specimens are going to be processed by the pathology department and cancers are going to be identified and classified by their molecular type. The investigators intend to know which is the disease reservoir in various ages.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

768

Conditions

Female Breast Cancer Male Breast Cancer

Interventions

Bilateral mastectomyPROCEDURE

Bilateral mastectomy and imaging study of cadaveric breasts

BiopsyOTHER

Biopsy of BI-RADS 3 and superior lesions

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female and male cadavers above 40 years Exclusion Criteria: * Known breast cancer * Breast tissue accidental damage

Outcomes

Primary Outcomes

Silent breast cancer prevalence

To define the existing disease that did not caused death in both sexes

Time frame: 2 years

Secondary Outcomes

Silent breast cancer prevalent molecular profile

To identify those molecular subgroups of the disease that remain silent

Time frame: 2 years

Data from ClinicalTrials.gov

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