Hepatic Fibrosis Assessment Using Multiparametric Magnetic Resonance Imaging

Seoul National University Hospital69 enrolled

Overview

The purpose of this study is to assess degree of hepatic fibrosis using multiparametric MRI for investigating difference between normal or early fibrosis and advanced fibrosis.

In patients with liver parenchymal disease or normal liver parenchyma who are scheduled to undergo either liver resection or liver biopsy are included. Referred patients undergo multiparametric MRI including perfusion, diffusion, elastography and fat quantification before surgery or biopsy. The pathophysiologic changes are evaluated using multiparametric MRI, and compared between normal/early fibrosis and advanced fibrosis.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Fibrosis Cirrhosis

Interventions

magnetic resonance imagingPROCEDURE

multiparametric MRI as follows: 1. diffusion weighted imaging using multiple b-values 2. Fat quantification sequence 3. perfusion MRI using ECCM agent 4. MR elastography \------------------------------------ 5. routine MRI using hepatocyte specific agent (optional in patients with focal liver lesion)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who are scheduled to undergo liver resection for focal liver lesion * patients who are scheduled to undergo liver resection or percutaneous biopsy for diffuse parenchymal disease * liver donor candidate who are scheduled to undergo preoperative liver biopsy or liver resection * AND patients/living donor candidates who sign informed consent Exclusion Criteria: Patients who have at least one of followings are excluded. * Patients who are contraindication for MRI contrast enhanced MRI. * Premenopausal female patients who are pregnant. * Patients who are physically compromised to acquire liver MRI

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

difference of portal flow between no or early hepatic fibrosis and advanced hepatic fibrosis

Time frame: in three years

Secondary Outcomes

difference of arterial flow between no or early hepatic fibrosis and advanced hepatic fibrosis

Time frame: in three years

difference of liver stiffness value between no or early hepatic fibrosis and advanced fibrosis

Time frame: in three years

monitoring of transient dyspnea after contrast media injection

Time frame: in three years

Data from ClinicalTrials.gov

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