Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure

Inclusion Criteria: 1. Subject is between 50 and 75 years of age. 2. Subject is classified as average risk per the American Gastroenterological Association Guidelines on Colorectal Cancer Screening: Individuals without a personal or family history of colorectal cancer (CRC) or adenomas, inflammatory bowel disease, or high-risk genetic syndromes. 3. Subject is willing and able to participate in the study procedures and to understand and sign the informed consent. Exclusion Criteria: 1. Subject with history of polyps (including those identified by computed tomography \[CT\], optical colonoscopy, sigmoidoscopy, etc.). 2. Subject with history of negative colon assessment (including CT, optical colonoscopy, sigmoidoscopy etc.) within 5 years as these subjects would be defined not requiring screening in this time frame. 3. Subject with suspected or diagnosed with hematochezia, melena, iron deficiency with or without anemia, or any other rectal bleeding, including positive fecal occult blood test of any variety. 4. Subject with any condition believed to have an increased risk of capsule retention such as suspected or known bowel obstruction, stricture, or fistula. 5. Subject with dysphagia or any swallowing disorder. 6. Subject with serious medical conditions that would increase the risk associated with capsule or colonoscopy that are so severe that screening would have no benefit. 7. Subject with a cardiac pacemaker or other implanted electromedical device. 8. Subject expected to undergo MRI examination within 7 days after ingestion of the capsule. 9. Subject with clinical evidence of renal disease, including clinically significant laboratory abnormalities of renal function within the past 6 months, or at any time in the past if not tested within the last 6 months, defined as creatinine, blood urea nitrogen (BUN), and/or glomerular filtration rate (GFR) outside of the local laboratory reference range. 10. Subject with known gastrointestinal motility disorders. 11. Subject with allergies or known contraindication to the medications or preparation agents used in the procedure as described in the relevant instructions for use. 12. Subject with comorbidities which, in the opinion of the investigator, will not be appropriate for the study or the subject has an estimated life expectancy of less than 6 months. 13. Subject is considered to be part of a vulnerable population (e.g. prisoners or those without sufficient mental capacity). 14. Subject is pregnant, suspected pregnant, or is actively breast-feeding. Females of child-bearing potential will be required to provide either a urine pregnancy test or serum pregnancy test as part of the participant's standard of care regardless of their participation in the study (except for subjects who are surgically sterile or are post-menopausal for at least two years). 15. Subject has participated in an investigational drug or device research study within 30 days of enrollment that may interfere with the subject's safety or ability to participate in this study.