The standard anesthetic care plan for people having adolescent idiopathic scoliosis surgery will be accompanied by a pharmacokinetic simulation of the administered drugs to suggest opportunities to adjust drug doses to achieve tolerable pain control after surgery, avoid respiratory depression and allow patients to respond quickly either during intraoperative testing or at the conclusion of surgery.
As part of this study, anesthesiologists will be given additional data on the expected drug effects based on a computer simulation. The data will be provided as a suggestion and will be used together with all the other information normally used to keep the study subjects safely asleep during surgery. In addition, data will be collected from the medical history and on postoperative pain control and medication side effects for the first 24 hours. Specifically, study subjects will be asked to rate their pain on a 10-point scale after they wake up from surgery and once they arrive in the pediatric intensive care unit. Measures of the time from the end of surgery until the study subjects are awake and out of the operating room will also be collected.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
14
The aim of the simulation is to recommend dosing adjustments to improve postoperative analgesia with a rapid emergence.
UF Health
Gainesville, Florida, United States
4-Item Pain Intensity Measure
0 - 10 (0=no pain; 10 = pain as bad as can be)
Time frame: 24 hours
Respiratory depression
Respiratory rate less than 10 breaths per minute (bpm), or administration of naloxone.
Time frame: 24 hours
Utility of pharmacokinetic simulation
The number of modifications to the anesthetic dosing
Time frame: 4 - 8 hours (Intraoperative period)
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