The purpose of this research study is to evaluate the use of NAC in the treatment of anosmia (a loss of the sense of smell). This drug is already approved by the Food and Drug Administration (FDA) for oral or pulmonary (lung) inhaled use for other medical conditions. However, there is research evidence that the medication may promote nerve recovery (help nerves work better after they are damaged). Since anosmia involves nerve problems, we believe the nasal spray may help treat anosmia. The medication has been in use for many years for other conditions, without safety problems.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
29
University of Miami, Miller School of Medicine, Clinical Research Building
Miami, Florida, United States
Change in the Smell Identification Test score
Sense of smell is measured using the Smell Identification Test (a standardized 40-item forced choice self administered microencapsulated odor "scratch-and-sniff" style test )
Time frame: Baseline and three months after completion of treatment
Change in Sino-Nasal Outcome Test (SNOT-20) score
Validated quality of life assessment tool for nasal and sinus disease patients
Time frame: Baseline and three months after completion of treatment
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