Feasibility of Measuring Exercise's Effects on Molecular Mechanisms of Disease Progression in Prostate Cancer

Vancouver Prostate Centre20 enrolled

Overview

The investigators aim to evaluate the feasibility of a larger clinical trial assessing an exercise program during the "teachable moment" in patients with prostate cancer and measuring its effect on tumor apoptosis signaling, lipogenesis and steroidogenesis. Participants will be randomized between a 4-12 week exercise program or to standard of care only. Participants will be assessed at screening, baseline (day 0), throughout the trial intervention (days 1-84), post-intervention visit (prior to radical prostatectomy) and final study visit 6-months post-radical prostatectomy. At each assessment, physical, biological samples and psychosocial assessments will take place.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Prostate Cancer

Interventions

Eligibility

Sex: MALEMin age: 19 Years

Medical Language ↔ Plain English

Inclusion criteria: * Completed Pre-Screening Consent Form * Men with CaP, who are deemed suitable by a urologist for RP * Engaging in \<90 minutes/week of moderate-to-vigorous exercise * BMI \<40 * Age \>19 * Able to speak and read English (to be able to complete questionnaires) * Willing to comply with all study procedures (including committing to twice-weekly visits to the study exercise facility and exercise at home) and be available for the duration of the study * Provide signed and dated informed consent form Exclusion Criteria: • Men with a medical, musculoskeletal condition or use of mobility aid that prevents participation in the exercise intervention.

Outcomes

Primary Outcomes

Feasibility: Number of patients screened per month

Time frame: From start of recruitment to end of recruitment

Feasibility: Number of patients enrolled per month

Time frame: From start of recruitment to end of recruitment

Feasibility: Proportion of screen eligible patients who enroll

Time frame: From start of recruitment to end of recruitment

Feasibility: Treatment-specific retention rates

Time frame: From date of randomization to end of treatment intervention for each participant, an average of 4-12 weeks

Feasibility: Rates of adherence to protocol for the exercise intervention arm and control arm

Time frame: From date of randomization to end of treatment intervention for each participant, an average of 4-12 weeks

Feasibility: Proportion of planned assessments that are completed respectively

Time frame: From date of randomization to end of study for each participant, an average of 7 months