Purpose: To evaluate the effects of replacing breakfast with a high protein, high fat, high fiber meal replacement in overweight individuals, on body composition. Participants: Healthy, overweight and obese individuals (ages 18-45 yrs) with no history of disease. Procedures (methods): In a randomized control intervention, subjects will complete 5 different testing sessions (pre-screening, 2 baseline testing sessions, and 2 post testing sessions) as well as an 8 week intervention period. Pre-screening will include written informed consent, health history questionnaire, nutrition analysis, and baseline anthropometric measures. Baseline testing will be split into two sessions and include measurements of resting metabolic rate (RMR), body composition, blood and saliva hormones, mood, satiety, and health related quality of life questionnaires, and a cardiorespiratory fitness assessment. Subjects will be randomly assigned to treatment (8 week supplementation with meal replacement to be taken at breakfast) and control groups (continue normal eating habits) with 4 electronic correspondences throughout the supplementation period. All measures will be repeated in two post-testing sessions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
50
Applied Physiology Laboratory
Chapel Hill, North Carolina, United States
Change in Fat Mass measured from multi-compartment (4C) model
Time frame: 0 to 8 weeks
Change in lean mass measured from multi-compartment (4C) model
Time frame: 0 to 8 weeks
Change in percent body fat measured from multi-compartment (4C) model
Time frame: 0 to 8 weeks
Change in resting metabolic rate using indirect calorimetry
Time frame: 0 to 8 weeks
Change in respiratory exchange ratio using indirect calorimetry
Time frame: 0 to 8 weeks
Change in total leptin concentrations from blood sample analysis
Time frame: 0 to 8 weeks
Change in LDL from blood sample analysis
Time frame: 0 to 8 weeks
Change in triglycerides from blood sample analysis
Time frame: 0 to 8 weeks
Change in insulin from blood sample analysis
Time frame: 0 to 8 weeks
Change in visceral fat from ultrasonography
Time frame: 0 to 8 weeks
Change in satiety via questionnaire
Time frame: 0 to 8 weeks
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