A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular Carcinoma

Seoul National University Hospital68 enrolled

Overview

The purpose of this prospective randomized study is to compare the efficacy and safety of radiofrequency ablation and hepatic resection for small hepatocellular carcinomas with very homogeneous underlying conditions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Carcinoma, Hepatocellular

Interventions

Hepatic resectionPROCEDURE

Anatomical surgical resection of the liver including the tumor

Radiofrequency ablationPROCEDURE

Percutaneous ablation using radiofrequency under the imaging guidance

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 20 and 70 years 2. Child-Pugh class A (score 5-6) 3. Single hepatocellular carcinoma 4. Maximal diameter of the tumor from 2 to 4 cm when measured on MRI or CT (The diameter on MRI was measured prior to that on CT) 5. No previous treatment 6. Platelet count \> 80,000/mm3 Exclusion Criteria: 1. HCC abutting main hepatic veins or the first branches of the main portal vein 2. HCC abutting vessels ≥ 0.5 cm

Outcomes

Primary Outcomes

The patient survival

Time frame: From the intervention up to 5 years or until the death of the participant whichever came first

Secondary Outcomes

The disease-free survival

Time frame: From the intervention up to 5 years or until hepatocellular carcinoma recurrence whichever came first

Data from ClinicalTrials.gov

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