The Use of Manuka Honey to Improve Healing After Third Molars Surgery

Damascus University50 enrolled

Overview

Since there is an evidence that Manuka honey is an antibacterial agent, the present study aims to confirm this characteristic and assess its effect in improving healing and reducing postsurgical symptoms, if topically applied after the surgical removal of impacted mandibular third molars

Sufficient evidence exists recommending the use of honey in the management of acute wounds and burns. Studies revealed that the healing effect of honey could be classified by its antibacterial, antiviral, anti-inflammatory and antioxidant properties of its components. Manuka honey has been shown to inhibit a wide range of microorganisms, including multiresistant strains. This unique honey is derived from flowers of manuka tree (Leptospermum scoparium) in New Zealand. Dihydroxyacetone and methylglyoxal are unique and naturally occurring constituents of manuka honey that correlate with its antibacterial activity. Since surgical extraction of impacted molars is one of the most common operations in the oral cavity and the postoperative symptoms disturbing the patient may reduce the quality of health service, this study aims to assess the healing potential of Manuka honey in reducing these symptoms by comparing the outcome of extraction of impacted lower molars with and without topical application of Manuka honey into the extraction socket.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Surgical Extraction of Impacted Third Molars

Interventions

Manuka HoneyBIOLOGICAL

This material is going to be placed into the sockets of the extracted third molars in the experimental group

Eligibility

Sex: ALLMin age: 20 YearsMax age: 37 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Asymptomatic, Symmetrical, Bilateral Impacted Third Molars Exclusion Criteria: * Uncontrolled diabetes, * Hypersensitivity to Honey * Alcoholism, * Drug abuse, * Pathological condition in the region

Locations (1)

Department of Oral and Maxillofacial Surgery, University of Damascus Dental School

Damascus, Damscus, Syria

Outcomes

Primary Outcomes

Levels of postoperative discomfort

Postoperative Symptom Severity (PoSSe) Scale will be used for this variable. The patient will be asked to fill in a questionnaire on the 7th day following surgery. This questionnaire is used to assess postoperative discomfort in patients who have third molars extracted. PoSSe Scale consists of 7 sub-scales that investigate the patient's ability to enjoy food; speak properly; perceive altered sensations, appearance, pain, and sickness; and interference with daily activities.

Time frame: 7 days after the surgical removal of third molars

Change of facial contours due to swelling

In order to assess facial swelling, the distances between the labial commissure and the tragus, and between the lateral canthus and the gonion will be measured. The change between 3 days and before surgery will give an idea about the amount of swelling that occurred following surgery. Between 3 days and 7 days will give an idea about the change that occurred in this period.

Time frame: Measurements will be taken before surgery, on the 3rd and on the 7th days after surgery.

Change of the masticatory muscles status

Mouth opening range will be assessed by measuring the distance between the upper and lower incisors using a vernier caliper when the patient is asked to open his/her mouth as much as possible. The presence of limited opening of the mouth is an indication of trismus.

Time frame: Measurements will be taken before surgery, on the 3rd and on the 7th days after surgery.

Pain and Change of pain

using a Visual Analog Scale of Faces (VASoF).

Time frame: This will be assessed on the 3rd and 7th day following surgery

The presence or absence of alveolar osteitis

The presence of a dry socket condition will be checked out at two time points.