This study aims to investigate the comparative effectiveness between polyp removal with or without electrical current. The investigators want to include 600 polyps in the trial. It is known that polyps have the potential to develop to cancer if left in situ, but the investigators do not know the best way to remove them completely.
In this study the investigators want to compare to widely used methods for polyp removal; hot and cold snare polypectomy. There has not been performed any big studies on this subject earlier, but current knowledge indicates that hot polypectomy (i.e. with use of electrical current) is somewhat better with regard to complete resection of polyps compared to cold polypectomy (without electrical current). In this project the patients will be randomized to either hot or cold polypectomy. The investigators will distribute videos of how the polypectomies should be performed, and a gastroenterologist in the project group will instruct the doctors examining the patients to make sure that everyone performs polypectomy according to current guidelines. The study is designed as a non-inferiority trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
429
Complete resection rate
We want to measure the rate of polyps that are resected completely, both with biopsies from the margin and the histopathologists evaluation of the resection margins of the polyp itself.
Time frame: Hopefully within 4 weeks, when the histopathologist has examined the biopsies
Complications
We want to register early (during the procedure) and late (within 4 weeks after the procedure) complications. Complications we will record is bleeding/blood in the stool, perforation and patient contact with health care provider
Time frame: 4 weeks
Factors explaining the primary outcome
Patient characteristics
Time frame: During the hospital stay and up to 4 weeks.
Factors explaining the primary outcome
Doctor characteristics
Time frame: During the hospital stay and up to 4 weeks
Factors explaining the primary outcome
Procedure characteristics
Time frame: During the hospital stay and up to 4 weeks
Factors explaining the primary outcome
Histology of polyps, correlation between resection margins and biopsies, correlation between optical and histopathological diagnosis
Time frame: During the hospital stay and up to 4 weeks
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