The purpose of this study is to evaluate the safety and efficacy of Apatinib combined with cytokine-induced killer cell (CIK) vs Apatinib as the third line therapy for patients with advanced gastric cancer.
400 patients with stage Ⅳ Gastric Cancer,who had received surgery and chemotherapy,will be randomly divided into group A(receive Apatinib and CIK treatment ) or group B(just receive Apatinib),and the randomize ratio will be 1:1. Patients in group A will receive 3 cycles of CIK treatment (every 1 year) and Apatinib (continuous).Patients in group B will receive only Apatinib (continuous) .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Cytokine-Induced Killer Cells are used to treat advanced gastric cancer patients with Apatinib.
Advanced gastric cancer patients take Apatinib 850mg qd by mouth.
Overall Survival(OS)
Time frame: 3 months
Disease-free survival
Time frame: 3 months
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