Safety, Tolerability, and Efficacy of 24 Weeks Simeprevir+Sofosbuvir for Chronic Hepatitis C Genotype 1

Inclusion criteria: 1. Adult 18-72 years 2. Cirrhosis: defined by stage 4 on biopsy or noninvasive tests or presence of splenomegaly and platelet of 130K or lower, or presence of shrunken nodular liver on CT or MRI, or presence of varices or encephalopathy or ascites. 3. HCV genotype 1 or indeterminate and later assessed at Screening and confirmed as genotype 1 Exclusion criteria: 1. Uncontrolled ascites, uncontrolled hepatic encephalopathy, or uncontrolled esophageal/gastric varices 2. Co-infection with HIV or hepatitis B (HBV) 3. CPT 7 or above, or MELD \>10 4. Total bilirubin 4.0 mg/dL or above 5. CrCl (creatinine clearance) \< 30 mL/min 6. Any unstable active medical illnesses. 7. Active use of illicit substances, alcohol, or smoking. 8. Any malignancy within last 5 years except for basal cell skin cancer that has been adequately treated or HCC within Milan or UCSF criteria, which will be acceptable 9. Any prior treatment with direct acting antivirals (approved or investigational), including HCV protease inhibitors, such as SMV. Patients who received prior treatment with SOF, and/or NS5A inhibitors (e.g. ledipasvir or Daclatasvir) can be included in this study 10. Platelet \< 30 K/uL