Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

David Travis Thomas7 enrolled

Overview

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Vitamin D Deficiency

Interventions

7 continuous days of aerobic trainingOTHER

For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

Eligibility

Sex: ALLMin age: 65 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 65-75 years of age Exclusion Criteria: * Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise. * Uncontrolled diabetes or hypertension. * History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity * History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months * Have a diagnosis of osteoporosis (as determined by DXA) * Participated in a resistance or aerobic training program in the last 3 months * Engage in more than 1 hr/week of vigorous activity * Body mass index \>29 * On hormone replacement therapy

Locations (1)

University of Kentucky

Lexington, Kentucky, United States

Outcomes

Primary Outcomes

Muscle VO2 consumption

The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.

Time frame: Up to 3 months

Data from ClinicalTrials.gov

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