Stroke Imaging Package Study

Wei-Hai Xu949 enrolled

Overview

Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.

1. Patients with acute ischemic stroke within 4.5-72h after onset were prospectively enrolled in our study and underwent standardized clinical and new imaging technique package assessment. 2. New imaging technique package mainly includes conventional cranial MRI （T1,T2,T2 FLAIR,DWI, and ADC), cranial magnetic resonance angiography (MRA), and intracranial vessel wall imaging (High-Resolution Magnetic Resonance Imaging,HRMRI) as well as susceptibility weighted imaging (SWI). 3. The neurofunctional fluctuation during hospitalization as well as 90-day outcomes were carefully assessed. Patients were followed up for 90-days after stroke onset. 4. Our study aims to explore the value of new imaging technique package in predicting early neurological deterioration (END) as well as 90-day unfavorable outcome in patients with acute ischaemic stroke.

Study Type

OBSERVATIONAL

Enrollment

949

Conditions

Acute Ischemic Stroke Intracranial Arteriosclerosis Cerebral Small Vessel Diseases

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with ischemic stroke and hospitalized during 4.5-72 hours after onset , confirmed by diffusion weighted imaging (DWI). 2. patients with stable vital signs. 3. patients who have underwent thrombolytic/intravascular therapy are allowed to enroll in the study. Exclusion Criteria: 1. patients with absolute/relative contraindication to MRI (including but not confined to metal in the body and claustrophobia). 2. patients who is extremely agitated, and cannot comply with MRI exam. 3. patients who declined the consent.

Locations (16)

Beijing Jishuitan Hospital

Beijing, Beijing Municipality, China

The Third Medical Center of Chinese PLA General Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

early neurological deterioration within 3 weeks after stroke onset (END-3 weeks)

END-3 weeks is defined as a significant neuro-functional decline \[increment of the National Institutes of Health Stroke Scale (NIHSS) ≥ 2 points \] within 3 weeks after admission.

Time frame: 3 weeks after stroke onset

90-days prognosis

90-days prognosis included two parts :1) stroke recurrence with new lesion on DWI;2) the modified Ranking Score (mRS) at 90-days after stroke onset.

Time frame: 90-days after stroke onset

Data from ClinicalTrials.gov

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