Study of Vosaroxin and Cytarabine for the Treatment of Adults 60 Years of Age or Older With Previously Untreated AML

Inclusion Criteria: * Age \> 60 years * A diagnosis of AML based on WHO classification (\>20% myeloblasts in peripheral blood or bone marrow) * No previous treatment with chemotherapy for AML, other than hydroxyurea. Previous treatment with hypomethylating agents is acceptable * Patients must have an ECOG (Zubrod) performance status of 0-2 (see Appendix I). * Patients must have adequate hepatic function with a total bilirubin \< 1.5 times upper limit normal (ULN) other than cases of Gilbert disease, and ALT and AST \< 2.5 times ULN; and adequate renal function as defined by a serum creatinine \< 2 times ULN. * Clinically significant nonhematologic toxicity after prior therapy has recovered to grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) version 4.03 or newer * Patients must have the ability to understand and the willingness to sign a written informed consent. A signed informed consent must be obtained prior to initiation of treatment * Left ventricular ejection fraction (LVEF) at least 40% by multiple gated acquisition (MUGA) scan or echocardiogram (ECHO) Exclusion Criteria: * Patients with known central nervous system (CNS) leukemia by spinal fluid cytology, flow cytometry or imaging. A lumbar puncture is not required unless CNS involvement is clinically suspected. Patients with signs or symptoms of leukemic meningitis or a history of leukemic meningitis must have a negative lumbar puncture within 2 weeks of study enrollment. * A diagnosis of acute promyelocytic leukemia (APL). The study does not require to rule APL out for every subject. However, if there is clinical suspicion for APL, such diagnosis has to be ruled out before initiation of treatment. * Active malignancy currently undergoing chemo or radiation therapy. Hormone therapy is acceptable. * Active serious infection that at the discretion of treating physician makes patient ineligible for chemotherapy.