Cisplatin Plus Raltitrexed or 5-fluorouracil Concurrent With Radiotherapy for Head and Neck Squamous Cell Cancer

Inclusion Criteria: * Pathologically confirmed untreated head and neck squamous cell cancer patients * 18-70 years * Clinical stage: T3-4N0-3M0 or T1-4N1-3M0 * Hematologic function: WBC ≥ 4.0×109/L, PLT ≥ 80×109/L, Hb ≥ 10mg/dL * Renal function: Cr ≤ 1.25×UNL * Hepatic function: BIL ≤ 1.5×UNL, ALT/AST ≤ 2.5×UNL * ECOG ≤ 1 * Woman and man of childbearing age must adopt contraception * With written consent Exclusion Criteria: * Malignant history * Pregnant or lactating women * With other severe diseases (blood, liver ,kidney or heart diseases) * Subjects not suitable for chemo-radiotherapy * Without written consent