Rivaroxaban for Scheduled Work-up of DVT - The Ri-Schedule Study

Inclusion Criteria: * Consecutive outpatients referred to ER because of suspected DVT * 18 years of age * Signed informed consent Exclusion Criteria: 1- refuse to consent Patients with the criteria below will not be eligible for scheduled work-up: 1. Duration of the diagnostic work-up is expected to last \< 2 hours 2. Presence of active cancer or receiving chemotherapy for cancer 3. Suspicion of coexisting clinical PE 4. Suspicion of active bleeding (gastrointestinal bleeding or muscle hematoma) 5. Signs of threatened circulation or having intractable pain in the lower extremity or may be considered as candidate for thrombolytic treatment 6. Physician does not consider it safe to discharge the patient 7. Presence of logistic factors that may hinder a scheduled work-up 8. Presence of co-morbid conditions that require hospital admission 9. Patient prefers not to be discharged before diagnosis is completed 10. Glomerular Filtration Rate \< 45 ml/min 11. Presence of contraindications to rivaroxaban including; * Lesion or condition, if considered to be a significant risk for major bleeding e.g current or recent gastrointestinal ulceration, presence of malignant neoplasms at high risk of bleeding, recent brain or spinal injury, recent brain, spinal or ophthalmic surgery, recent intracranial haemorrhage, known or suspected oesophageal varices, arteriovenous malformations, vascular aneurysms or major intraspinal or intracerebral vascular abnormalities * Concomitant treatment with any other anticoagulants e.g. unfractionated heparin (UFH), low molecular weight heparins (enoxaparin, dalteparin, etc.), heparin derivatives (fondaparinux, etc.), oral anticoagulants (warfarin, dabigatran etexilate, apixaban etc.) * Hepatic disease associated with coagulopathy and clinically relevant bleeding risk including cirrhotic patients with Child Pugh B and C. * Pregnancy/positive pregnancy test and breastfeeding (see section 4.6) 11\. Hb \< 11 g/dl 12. Presence of drug interaction with rivaroxaban including concomitant systemic treatment with azole-antimycotics (such as ketoconazole, itraconazole, voriconazole and posaconazole) or HIV protease inhibitors (e.g. ritonavir), acetylsalicylic acid at a dose higher than 160 mg or platelet aggregation inhibitors