The objective of this study is to detect BOS in an early stage by using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust and automated segmentation algorithms will be developed for these parameters, focusing on quantitative computed tomography (CT) image analyses to provide the physician a more sensitive diagnostics tool. The evolution of rejection over time will be monitored using non-rigid image registration methods.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
10
A HRCT scan at Functional Residual Capacity (FRC) and Total Lung Capacity (TLC) will be taken on visit 2, visit 3, visit 4, visit 5, visit 6, and visit 7. An upper airway (UA) scan will be taken on visit 2.
Antwerp University Hospital
Edegem, Antwerp, Belgium
Change in Airway Volume (iVaw) using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Airway Resistance (iRaw) using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7. Airway resistance is defined as the pressure drop over the airways divided by the airflow.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Specific Airway Volume (siVaw) using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Specific Airway Resistance (siRaw) using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Lobe Volumes (iVlobes) using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Air trapping using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7. Air trapping is defined as the regions in the lung with a gray value on the CT-scan image smaller than -850 HU at functional residual capacity.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Internal Lobar Airflow Distribution using FRI
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Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7. Airflow distribution is defined in as the percentage of air going to every lobe when inhaling from FRC to TLC and is calculated for every lobe as: IALDlobe \[%\] = 100 (VTLC\_lobe - VFRC\_lobe) / (VTLC\_lungs - VFRC\_lungs).
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Low Attenuation or Emphysema Score using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Blood Vessel Density or Fibrosis Score using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant
Change in Airway Wall Thickness using FRI
Exploratory imaging endpoints: HRCT scan will be taken at visit 2- visit 7.
Time frame: 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months post-transplant