The investigators planned to research the effect of vitamin D supplementation on the incidence of contrast-induced nephropathy in patients undergoing coronary angiography.
Vitamin D is primarily generated in the skin, in response to direct absorption of ultraviolet B radiation. Vitamin D can also be obtained through fortified foods and oral supplements. Contrast-induced nephropathy (CIN) is a generally reversible form of acute kidney injury that occurs mostly within 2-3 days of exposure to contrast medium (CM). The estimated incidence of CIN ranges from 2%-50%, and coronary angiography (CAG) or percutaneous coronary intervention (PCI), or both, are associated with CIN in about half of cases. Recently low vitamin D status has been shown to be associated with increased risk of CIN. However, its effects on CIN patients remain unclear. The investigators planned to determine the efficacy of vitamin D on the incidence of contrast-induced nephropathy in patients undergoing coronary angiography. This study may shed light as to whether oral vitamin D supplementation can be an adjunct therapy in CIN patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
306
2000 IU vitamin D3 tablets were taken daily for 6 days
2000 IU placebo tablets were taken daily for 6 days
PLA General Hospital
Beijing, Beijing Municipality, China
RECRUITINGthe prevalence of contrast-induced nephropathy
The primary efficacy variable was the prevalence of CIN between the vitamin D group and the control group.
Time frame: 48-72h after treatment
a change in serum creatinine level
The change in serum creatinine level was measured at 1, 2, 3 days after the procedure.
Time frame: at 1, 2, 3 days after percutaneous coronary intervention
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