Efficacy and Safety of SANGUINATE™ for Reduction of Delayed Graft Function in Patients Receiving a Kidney Transplant

Inclusion Criteria: 1. Able to understand and provide written informed consent. 2. Male or female subject at least 18 years of age. 3. Dialysis-dependent renal failure initiated at least 3 months prior to transplantation. 4. Subject is to be the recipient of a first kidney transplant from a deceased donor (brain death criteria). 5. Is able to receive intravenous infusions of study drug. 6. Anticipated donor organ cold ischemia time \< 30 hours. 7. A calculated prediction of DGF risk of least 25%. 8. Females of childbearing potential must agree to use 2 forms of effective birth control regimen (at least one-barrier method) during the initial 30-day study period. 9. Male subjects must agree to use condoms or other suitable means of pregnancy prevention. Exclusion Criteria: 1. Has received a blood transfusion of packed red blood cells (PRBC), other than with leukocyte-poor blood, within the 90-day period prior to screening. 2. Recipient of a live donor kidney or a kidney from a donation after cardiac death (DCD) donor. 3. Recipient of donor kidney preserved with normothermic machine perfusion. 4. Is scheduled to undergo multi-organ transplantation. 5. Has planned transplant of kidney(s) from a donor \< 6 years of age. 6. Has planned transplant of kidneys that are implanted en bloc (dual kidney transplant). 7. Has planned transplant of dual kidneys (from the same donor) transplanted not en bloc. 8. Body Mass Index (BMI) \> 38 kg/m2 9. Is scheduled for transplantation of a kidney from a donor who is known to have received an investigational therapy (under another Investigational New Drug) for ischemic/reperfusion injury immediately prior to organ recovery. 10. Is scheduled to receive an blood type-incompatible donor kidney. 11. Has undergone desensitization to remove antibodies prior to transplantation. 12. Total bilirubin \> 1.5 mg per dL, transaminase more than twice the upper limit of normal or evidence of hepatic insufficiency 13. Has participated in an investigational study within the last 30 days or received an investigational product within 5 half-lives of the study drug administration, whichever is longest. Potential subjects participating in a strictly observational study or a study involving approved treatments should be discussed with the Medical Monitor. 14. Has a history of human immunodeficiency virus (HIV) 15. History or presence of active substance abuse (illicit drugs or alcohol) in the previous 6 months, as believed by the Investigator 16. Presence of ECG-based evidence of acute myocardial infarction, unstable angina, decompensated heart failure, third degree heart block or cardiac arrhythmia associated with hemodynamic instability 17. History or presence of any disease or psychiatric condition that in the Investigator's assessment that would increase the risk to subjects associated with study participation, drug administration or interpretation of results 18. History of biopsy-confirmed malignancy within 5 years of randomization, with the exception of adequately treated basal cell or squamous cell carcinoma in situ skin lesions, carcinoma of the cervix in situ, or early detected prostate cancer. 19. Female subject who is pregnant or breast feeding.