The purpose of the study is to compare the intratumoral biodistribution of FAZA and F-miso in patients with non-small cell lung cancer and correlate the results of PET scans with immunohistochemistry.
The aim of the study is to compare the biodistribution of the two tracers specific for hypoxia in patients with non-small cell lung cancer. Two PET scans will be performed with FAZA and F-Miso tracers. The time between these twi PET scans will be 24 hours. another 24 hours after the late PET scan, the surgery will be done and a piece of tumor will be collected. Piece of tumor will be analysed by immunohistochemistry for hypoxia markers. The results of immunohistochemistry will be correlated with the biodistribution of the two tracers.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
23
2 PET scans will be performed before surgery : the first one with F-Miso tracer and the second, 24 hours later, with FAZA tracer
2 PET scans will be performed before surgery : the first one with FAZA tracer and the second, 24 hours later, with F-Miso tracer
Centre Henri Becquerel
Rouen, France
Comparison of hypoxia with FAZA and F-Miso tracer
SUV max, SUV mean and SUV peak were calculated for FAZA PET and Fmiso PET and will be correlated with results of immunohistochemistry
Time frame: one year
overall survival
time between inclusion and the death whatever the cause
Time frame: one year
disease-free survival
time between inclusion and the progression or death
Time frame: one year
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