The aim of the study is to measure tumoral angiogenesis modifications by RGD-K5 PET/CT before and after 2 cycles of chemotherapy in patients with lymphoma and a large tumoral mass
After inclusion PET scans with FDG tracer and with a specific tracer of angiogenesis will be performed on patient with lymphoma. After two cycles of chemotherapy PET scans with the same tracers will be performed. Overall survival and disease free survival will be monitored during 18 months.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Enrollment
21
PET scan with a tracer specific for angiogenesis (RGD K5) will be performed before and after 2 cycles of chemotherapy
Centre Henri Becquerel
Rouen, France
Measure of angiogenesis with RGD K5 PET scan
Measure of fixation, metabolic volume and angiogenic volume with RGD K5 traver
Time frame: 3 months
Measure of angiogenic volume with K5 tracer
Measure of SUV max, SUV peak, SUV mean, metabolic volume and angiogenic volume to determine angiogenesis parameters with RGD-K5 PET scansand correlation with results of anatomopathology.
Time frame: 3 months
Overall survival
Time between inclusion and death whatever the cause
Time frame: 18 months
Disease-free survival
Time between inclusion and progression or death
Time frame: 18 months
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