Variability of Fluconazole Concentration in Critically Ill Patients

University Medical Center Groningen50 enrolled

Overview

Fluconazole is the first-line agent in the treatment of invasive candidiasis. Studies showed inappropriate drug exposure causes high mortality in critically ill patients. Under-dosing and ineffective fluconazole trough serum concentrations were found in a recent retrospective study. Variability in fluconazole exposure can be easily measured with therapeutic drug monitoring. For patient groups who are at risk for drug underexposure, therapeutic drug monitoring can be valuable regards decreasing mortality.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Invasive Candidiasis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient is 18 years or older. * Treatment with fluconazole. * Written informed consent obtained from patient. * Written informed consent obtained from representative of patient. Exclusion Criteria: * Blood sampling not possible

Locations (1)

University Medical Center Groningen

Groningen, Netherlands

Outcomes

Primary Outcomes

Plasma concentrations of fluconazole in critically ill patients

Plasma concentrations of fluconazole will be determined using a validated method involving LC-MS/MS

Time frame: Up to one month

Data from ClinicalTrials.gov

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