The purpose of this study is to investigate whether a weight reduction with "Hepafast" in combination with raw food and vegetables for two weeks followed by a meal substitution with "Hepafast" and a calorie restriction in accordance with the Low Glycemic and Insulinemic Diet (LOGI) for 10 weeks is superior regarding improvement of non-alcoholic Fatty Liver Disease (NAFLD) compared to a conventional weight reduction in accordance with the LOGI diet without use of "Hepafast" for 12 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
University of Hohenheim
Stuttgart, Germany
change from baseline in hepatorenal index at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in fatty liver index at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in the classification of non-alcoholic fatty liver disease (NAFLD) based on ultrasound at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in body weight at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in blood pressure (systolic and diastolic) at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in GGT at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in GOT at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
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Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in GPT at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in AP at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in triglycerides at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in HDL cholesterol at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in LDL cholesterol at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in fasting glucose at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in insulin at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in HbA1c at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.
change from baseline in hsCRP at two weeks, six weeks and twelve weeks after starting a defined way of nutrition
Time frame: Participants will be followed for the time of twelve weeks. Examinations take place at two weeks, six weeks and twelve weeks.