Intraosseous Transcutaneous Amputation Prosthesis

Inclusion Criteria: * Trans-femoral amputation * 6 months or more attempted prosthetic rehabilitation (use of walking aids not relevant) * Between the ages of 18 to 60 inclusive * Length of stump: Sufficient bony stock for bony integration (at the investigator's discretion) and sufficient clearance (at the investigator's discretion) from medial joint line to accommodate failsafe device/ adaptor and knee mechanism * Suitable soft tissues to perform the operative procedure * Flexion Deformity (FFD) at hip no more than 15° * Normal range of flexion and adduction other than FFD * Oxford Grade 4 muscle power in all groups around hip * Normal contralateral leg function * Psychologically suitable (as deemed by screening process) * Sufficient standard of English to understand the Patient Information Sheet and general study requirements * Ability to understand and comply with study requirements - notably study timelines and additional clinic visits * Patients willing to take part in the study and sign the Informed Consent form Exclusion Criteria: * Radiotherapy to target limb at any time * Chemotherapy within the preceding 12 months * Cognitive impairment likely to affect participation * Pre-existing ipsilateral hip pathology * Limited cardiorespiratory reserve / inability to walk at normal pace * Any significant co-morbidity that, in the investigator's opinion, is likely to affect outcome (e.g. osteoporosis, heart disease, peripheral vascular disease, obesity or unrelated cancer) * Any co-morbidity in the contra-lateral leg that precludes walking * Any significant previous infection within the previous 12 months, such as apical stump sepsis or dental sepsis * MRSA * Using another silver-dosed medical device/treatment * Patients with hypersensitivity to silver * Concurrent medico-legal proceedings taking place * Patients currently included in other clinical trials